Amyotrophic lateral sclerosis (ALS) is a progressive neuro-degenerative disease that affects nerve cells in the brain and the spinal cord. A-myo-trophic comes from the Greek language. "A" means no. "Myo" refers to muscle, and "Trophic" means nourishment – "No muscle nourishment." When a muscle has no nourishment, it "atrophies" or wastes away. "Lateral" identifies the areas in a person's spinal cord where portions of the nerve cells that signal and control the muscles are located. As this area degenerates it leads to scarring or hardening ("sclerosis") in the region. ALS stem cell therapy is showing to be a great treatment for patients suffering with Amyotrophic lateral sclerosis.
Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in ALS eventually leads to their demise. When the motor neurons die, the ability of the brain to initiate and control muscle movement is lost. With voluntary muscle action progressively affected, people may lose the ability to speak, eat, move and breathe. The motor nerves that are affected when you have ALS are the motor neurons that provide voluntary movements and muscle control. Examples of voluntary movements are making the effort to reach for a smart phone or step off a curb. These actions are controlled by the muscles in the arms and legs.
The cause of ALS is not known, though an important step toward determining the cause came in 1993 when scientists discovered that mutations in the gene that produces the Cu/Zn superoxide dismutase (SOD1) enzyme were associated with some cases (approximately 20%) of familial ALS. This enzyme is a powerful antioxidant that protects the body from damage caused by superoxide, a toxic free radical generated in the mitochondria. Free radicals are highly reactive molecules produced by cells during normal metabolism again largely by the mitochondria. Free radicals can accumulate and cause damage to both mitochondrial and nuclear DNA and proteins within cells.
Our treatment program looks at tacking the possible route cause by triggering unstable free radical scavenger mechanisms, and repair to the damaged neutrons using mesenchymal stem cells.
ALS Cell Therapy:
Mesenchymal Stem Cells (MSCs) are very attractive multipotent cells for ALS Cell therapy because of their great plasticity and their ability to provide the host tissue with growth factors and to modulate the host immune system.
Mesenchymal Stem Cells (MSC) transplantation increases neuron survival and prevents gliosis, as microglia and strocytes are both the target and cause of neuroinflammation, Mesenchymal Stem Cells (MSCs) can rescue neurons and oligodendrocytes from apoptosis through the release of trophic and anti-apoptotic molecules, resulting in the induction of a neuroprotective microenvironment.
In addition, Mesenchymal Stem Cells (MSCs) can promote the proliferation and maturation of local neural precursor cells, leading to their differentiation into mature neurons and oligodendrocytes.
Amyotrophic Lateral Sclerosis (ALS) patients treated with cell therapy shown improvements in the following areas:
• Motor function
• Neuropathic Pain • Fatigue
- Slowed down progression and more
What Are Stem Cells:
Stem cells are unprogrammed cells in the human body that can be described as "shape shifters." These cells have the ability to change or “differentiate” into other types of cells. Stem cells are at the center of a new field of science called regenerative medicine. Because stem cells can become neurons, bone, muscle, cartilage and other specialized types of cells, they have the potential to treat many diseases, including Parkinson's, Alzheimer's, Diabetes and more.
Stem cell therapy is an intervention strategy that introduces new adult stem cells into damaged tissue in order to treat disease or injury. Many medical researchers believe that stem cell treatments have the potential to change the face of human disease and alleviate suffering. The ability of stem cells to self-renew and give rise to subsequent generations with variable degrees of differentiation capacities, offers significant potential for generation of tissues that can potentially replace diseases and damaged areas in the body, with minimal risk of rejection and side effects.
Purified Mesenchymal Cell Therapy from the Umbilical cord
Mesencymal stem cells are early passage multipotent progenitor cells derived from human cord blood that are capable of supporting hematopoiesis and differentiating into multiple lineages (osteogenic, adipogenic, chondrogenic, neurogenic, myogenic, and cardiomyogenic.)
For acceptance: Maternal blood and cord blood is tested negative for HIV I&II, HCV, CMV IgG/IgM, syphilis IgG/IgM antibodies and Hepatitis B surface antigen. Free of bacterial and fungal contamination.
Umbilical cord tissue represents a unique, easily accessible, and noncontroversial source of early stem cells that can be readily manipulated. Studies that have compared the properties of mesenchymal stem cells derived from cord tissue with those derived from adult sources (such as bone marrow) have illustrated some important differences:
- Cord tissue–derived mesenchymal stem cells appear to lack some immune suppression properties compared with adult mesenchymal stem cells.
- Cord tissue–derived mesenchymal stem cells lack class II HLA, whereas adult mesenchymal stem cells express these antigens. This may be particularly important in facilitating the “acceptance” of transplanted mesenchymal stem cells.
- Cord tissue–derived mesenchymal stem cells also express a range and level of specific cytokines that are different from those expressed by adult mesenchymal stem cells.
Thus, as naïve cells, mesenchymal stem cells extracted from cord tissues have greater therapeutic potential than adult cells. Studies have also shown that cord tissue–derived mesenchymal stem cells appear to have greater in vitro capacity for expansion and shorter doubling times; they can therefore generate a larger cell mass in less time than can be achieved with adult stem cells. This property may be related to greater length of chromosomal telomeres, which have been found to shorten with increased rounds of cell division. This suggests that primitive mesenchymal stem cells have a greater ability to expand in culture than do adult mesenchymal stem cells, perhaps due to their relative youth.
Aging & Disease Onset
Repopulate Your Stem Cell Pool
In order to self-repair, living organisms have stem cells in central and peripheral locations which can be attracted to sites of injured tissues by “alarm signals”. In this way, these cells proliferate, migrate, and accumulate in those damaged sites. If this situation of “alarm” perpetuates, stem cells could be permanently exhausted from their original locations leading to irreversible disease.
Basically, it could be a matter of stem cell quantity and effective availability at a certain time point when active regeneration is needed. The expected consequences of this situation could be the lack of an appropriate number of stem cells for further tissue replacement and regeneration and eventually the development of disease and aging.
For example, we could think that any alteration of this stem cell homeostasis by constant and repetitive trauma, physical hyperactivity, chronic inflammation and chronic disease could provoke a persistent disequilibrium inside all these reserve locations. This could promote an irreversible and premature stem cell exhaustion, being impossible then for the organism to self-repair and survive.
As we age we have less circulating stem cells. Introduction of new stem cells to our bodies circulation can improve health and repopulate our stem cell pool.
How Long Will It Take To See Improvement:
This is one of the most common and important questions a patient can ask. Keep in mind that every patient who receives any type of medical procedure will react differently to their treatment. Patients who have received stem cell therapy through StemCells21 generally see the full culmination or their results from almost immediately to a few months later. Some patients have taken up to 6 months before seeing the full effect of the treatment.
Supportive Therapies in our ALS program:
• General rejuvenation peptide complex injections: stimulates stem cells into repair mode
• Condition specific peptide complex injections: triggers higher repair signals in specific tissues such as neurons, brain, central nervous system
• 30 days self administration enzyme therapy: Human PolyEnzyme mix
• IV and local tissue laser therapy: changes the bloods micro environment and local tissue activity
• IV oxygen therapy: increased oxygen levels in blood supporting healthy cells
• IV vitamins: IV curcumin giving a powerful anti-inflammatory effect (also combined with blue laser is a powerful photodynamic therapy)
• Take home customised nutrition package made specific to your blood test results. (comprehensive blood test analysis will be made)