Optic Nerve Atrophy is a name given to a group of conditions: some are genetic disorders effecting the eye & nerves, while others are related to trauma, toxins, inflammation, and a range of other conditions. Optic nerve atrophy is when the optic nerve has reduced capacity to relay information of what the eye is seeing. The optic nerve transports images of what the eye is seeing as electrical impulses, from the retina to our brain.
Symptoms of Optic Nerve Atrophy
- Blurred vision.
- Decrease in visual function such as a decrease in sharpness and clarity of vision (visual acuity) or decreases in side (peripheral) vision.
- Poor constriction of the pupil in light.
- Decreased brightness in one eye relative to the other.
- Change in the optic disc.
Stem Cell Treatment for Optic Nerve Atrophy:
At our facility we perform a combination treatment program with the focus being Mesenchymal stem cells. These cells are used with a combination of supportive therapies including:
- IV laser treatment + local tissue lasers: increase blood flow and cellular activity near the eye
- Peptides & Growth factors: to increase cellular activity in the optic nerve
- Nutrition & Enzymes: to support health cellular functions
The ability of stem cells for eye disease treatment is of great interest to both researchers and clinicians because currently there is no therapy to cure ocular neurodegenerative diseases & Injury. The use of naïve Mesenchymal stem cells are showing great benefit to patients with both eye disease & trauma related conditions of the eye. This is because the stem cells used can stimulate new formation of Ocular stem cells including limbal (corneal) stem cells, conjunctival stem cells, retinal stem cells and nerve cells.
Although the retina is a complex structure, Stem cell migrations supported with increase repair signals have the ability to repair this structure. Firstly the stem cells will improve the epithelial monolayer: the retinal pigment epithelium (RPE). Although the RPE is not a defined part of the retina, it is an essential supporting tissue involved in retinol cycling, nutrient transport, growth factor production and phagocytosis of the fragile photoreceptor (PR) outer segments (OSs). This regeneration of the eye cells will aid the cells repair of the optic nerve. MSCs have the ability to differentiate into neural cells and secrete neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factors (GDNF), which may promote differentiation of the grafted cells into neural cells, inhibit apoptosis, improve angiogenesis, suppress an inflammatory infiltrate, and maintain grafted cell survival.
Our treatment works in multiple mechanisms which include:
Promote Myelinaon: facilitates migration and proliferation of oligodendrocyte precursors to the sites of myelin damage. It directly regulates key structural proteins that comprise myelin. NGF also induces the secretion of brain-derived neurotrophic factor (BDNF), another integral neurotrophin involved in myelination.
Promote Axonal Regeneration: promote directional guidance to regenerating axons and their selective application, which, in turn, may help to improve functional recovery.
Promote Neuronal Survival: maintain the survival of sympathetic neurons in vitro and is required for their target dependent survival in vivo. NGF promotes survival via activation of its receptor tyrosine kinase, TrkA.
Promote Synaptogenesis: lead to significant compensatory changes in the terminal region and synaptic junctions in adult centralized nervous system, thereby promoting synaptic remodeling and generation.
Improvements in the Treatment of Optic Nerve Atrophy with Stem Cells:
- Visual acuity
- Light perception
- Field of vision
- Night vision
- Colour vision